Adolescent-onset GABAAα1 silencing regulates reward-related decision making
نویسندگان
چکیده
منابع مشابه
Adolescent-onset GABAA α1 silencing regulates reward-related decision making.
The GABAA receptor mediates fast, inhibitory signaling, and cortical expression of the α1 subunit increases during postnatal development. Certain pathological stimuli such as stressors or prenatal cocaine exposure can interfere with this process, but causal relationships between GABAA α1 deficiency and complex behavioral outcomes remain unconfirmed. We chronically reduced GABAA α1 expression se...
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BACKGROUND Neural mechanisms of decision-making and reward response in adolescent cannabis use disorder (CUD) are underexplored. METHODS Three groups of male adolescents were studied: CUD in full remission (n=15); controls with psychopathology without substance use disorder history (n=23); and healthy controls (n=18). We investigated neural processing of decision-making and reward under condi...
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Phenomenological models of decision-making, including the drift-diffusion and race models, are compared with mechanistic, biologically plausible models, such as integrate-and-fire attractor neuronal network models. The attractor network models show how decision confidence is an emergent property; and make testable predictions about the neural processes (including neuronal activity and fMRI sign...
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ژورنال
عنوان ژورنال: European Journal of Neuroscience
سال: 2015
ISSN: 0953-816X
DOI: 10.1111/ejn.12995